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Febrile Seizure & Vaccines

Studies published over the past two decades clearly indicate that certain vaccines and vaccine combinations “independently increase a child’s risk of developing a febrile seizure.” This consistent finding has generated surprisingly little concern among most vaccine researchers, who dismiss the risk as “small.” However, the challenges to long-term neurological health associated with febrile seizures that occur at the very same young ages when children are receiving numerous vaccines highlight the importance of paying attention to vaccine-induced seizures.

The number of vaccines associated with increased febrile seizure risk is not insignificant. These include:

  • Both measles-mumps-rubella (MMR) and measles-mumps-rubella-varicella (MMRV) vaccines (depending on the study);

  • The combination vaccine that includes antigens for diphtheria, tetanus, acellular pertussis, polio and Haemophilus influenzae type b (DTaP-IPV-Hib);

  • The 7-valent pneumococcal conjugate vaccine (PCV7);

  • Trivalent inactivated influenza vaccine (IIV3) (when administered on the same day as either the PCV7 or DTaP vaccines);

  • H1N1 influenza vaccine; and

  • The more “reactogenic” DTP vaccine (diphtheria, tetanus and whole-cell pertussis) used in many low-resource countries.

In 2010, Australia “abruptly” suspended use of seasonal influenza vaccine in children at or under age five after many children experienced “unforeseen severe febrile reactions and febrile seizures” (5-7 seizures per 1000 doses of vaccine administered). Extensive investigations failed to find a definitive cause for the unusual febrile responses but zeroed in on one particular manufacturer as the likely source. The two vaccines produced by that manufacturer generated elevated fever in 23% to 37% of children aged 6-35 months, whereas fever estimates were about 5% for influenza vaccines produced by other manufacturers.

Read the full article here


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